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rFactor Crack 1 255 Download Game. rFactor lite.Differential effects of chronic, intermittent hypoxia and room air on arterial stiffness and vasoconstriction in rats. This study was performed to investigate the differential effects of chronic intermittent hypoxia (CIH) and room air (RA) on arterial stiffness and vasoconstriction. Adult male Sprague-Dawley rats were exposed to CIH (n = 10) or RA (n = 10) for 14 days in different protocols. CIH was performed by cyclic switching of inspiratory oxygen fraction (FiO2) from room air (RA) to 100% for 5 min followed by a return to RA for 3 min. Rats were exposed to RA for 5 min or to 100% oxygen for 3 min. Arterial stiffness was assessed using pulse-wave analysis (PWA). Vessel function was evaluated using pressurized infusions of methoxamine (MOX) and sodium nitroprusside (SNP). Arterial stiffness was determined by the pulse wave velocity (PWV). PWA parameters were calculated after 25-min stabilization. The contractile responses to MOX and SNP were measured in the third and fifth aortic ring. Arterial distensibility was significantly lower in CIH compared with RA (delta(25 min) mm Hg/mm Hg: CIH vs RA: -0.24+/-0.23 vs 0.33+/-0.35, p









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